Radical Scavenging activity and phytochemical screening of the leaf extract of Synsepalum dulcificum (Schumach. & Thonn.) Daniell

Antioxidants are chemicals that possess bioactive constituents which usually allow them to fight against free radicals. Antioxidant and phytochemicals properties of the leaves Synsepalum dulcificum were investigated using ethyl-acetate, ethanol methanol extracts. 2, 2-diphenyl-picrylhydrazyl (DPPH) scavenging activity, total antioxidant ferric reducing power (FRAP), flavonoid phenolic content was carried out. The phytochemical screening assay done on following: Alkaloids, saponin, flavonoids, tannin, anthraquinones, terpenoids, cardiac glycosides, phlobatannin test solvent results gotten for revealed gave highest extract yield (17.4%) while ethyl-acetate had least (5.0%). At 250 μg/ml concentration, methanolic amount with IC50 values (89.94 μg/ml), followed by (68.20 μg/ml)) ethyl acetate activity (39.21 these significantly different (P<0.05). Total (ascorbic acid equivalent) at S. ranged from 41.7 AAE in 58.98 extract. Furthermore, (FRAP) leaf extracts (0.29μmolFe2+/g) reduction potential, (0.28μmolFe2+/g) (0.26μmolFe2+/g). 0.02μg/ml TAE–0.09μg/ml TAE 1000μg/ml concentration 0.32mg/g QE 14.38mg/g This study suggests exhibit great potential ability could oxidative stress.